Fig. 2: Effect of variant on beta-cell function and 2 hour stimulated glucose levels. | Communications Medicine

Fig. 2: Effect of variant on beta-cell function and 2 hour stimulated glucose levels.

From: XBP1 expression in pancreatic islet cells is associated with poor glycaemic control especially in young non-obese onset diabetes across ancestries

Fig. 2: Effect of variant on beta-cell function and 2 hour stimulated glucose levels.

a Box plot showing additive models of XBP1 eQTL variant (rs7287124) and log-transformed Homeostasis Model of Assessment of Beta-Cell function (HOMA-B) calculated using fasted glucose and stimulated C-peptide in 470 individuals with newly diagnosed type 2 diabetes at DMDSC, Chennai, India. After adjustment for age, sex, BMI, and HOMA-B, the association remained significant (P = 5 × 10−3). b Boxplot showing effect of rs7287124 on 2 hr stimulated blood sugar in 484 rural-dwelling Indians from the TREND study. After adjustment for age, sex, and BMI, the association remained significant (P = 0.02). Per allele was associated with 0.7 mmol/L higher 2 h glucose (95% CI: 0.1–1.4).

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