Fig. 3: Trans-ancestry meta-analyses of the effect of rs7287124 on HbA1c levels overall and in young, lean T2DM cases. | Communications Medicine

Fig. 3: Trans-ancestry meta-analyses of the effect of rs7287124 on HbA1c levels overall and in young, lean T2DM cases.

From: XBP1 expression in pancreatic islet cells is associated with poor glycaemic control especially in young non-obese onset diabetes across ancestries

Fig. 3: Trans-ancestry meta-analyses of the effect of rs7287124 on HbA1c levels overall and in young, lean T2DM cases.

Forest plots showing random effects of XBP1 eQTL variant on HbA1c (mmol/mol). Effects are pooled across summary statistics available from the MAGIC consortium for East Asians, Europeans, and South Asians without T2DM (n = 173,186) and for 6482 individuals with newly-diagnosed T2DM across 4 cohorts: Tayside Scotland (TDS), urban-dwelling South Asian Indians (DMDSC), rural-dwelling South Asian Indians (TREND), and British South Asian Pakistani and Bangladeshis (G&H). The random effect meta-analysis shows an increase of 4.32 mmol/mol of HbA1c per risk allele (95% CI: 2.60–6.04). Forest plots of sub-groups of people with newly diagnosed T2DM showed a stronger effect in 477 individuals diagnosed young with non-obese BMI (6.41 mmol/mol), compared to no effect in those diagnosed older with non-lean BMI (n = 3382).

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