Table 1 Allele frequencies across ancestries and effects of lead eQTL variant on XBP1 expression in pancreatic beta-cells, T2DM risk

From: XBP1 expression in pancreatic islet cells is associated with poor glycaemic control especially in young non-obese onset diabetes across ancestries

Variant

Chr: base position

Beta Islet Expression (InsPIRE), P value

Z score, P value

Islet Expression

(TIGER)

1000 G

European EAF (G)

1000 G

South Asian EAF (G)

1000 G

African EAF (G)

1000 G

East Asians EAF(G)

Beta T2DM

(Biobank Japan)

Beta Diabetes

(DIAM ANTE)

rs7287124

A > G

22:

29239157

−0.18, 2.9 × 10−4

−4.53, 5.8  × 10−6

0.24

0.54

0.45

0.65

0.04, p = 4.6 × 10−6

0.02,

p = 1.4 × 10−4

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