Table 2 Comparisons of hippocampal subregions volume changes (follow-up minus baseline)

From: Longitudinal MRI identifies associations between cognitive decline, inflammatory markers, and hippocampal subregion volumes in individuals with knee osteoarthritis

 

dementia-non-converters (n = 21)

dementia-converters (n = 15)

t/Wald χ²

95% CI

P

FDR p Value

Whole hippocampusa

−133.46 ± 204.28

−152.89 ± 180.90

0.679

(185.775, −93.108)

0.503

 

Hippocampal tailb

−54.21 ± 86.17

−54.12 ± 81.31

0.029

(50.929, −49.508)

0.977

1.066

Subiculumb

−13.83 ± 33.83

−11.32 ± 36.03

−0.615

(10.913, −20.334)

0.543

1.629

CA1b

−2.63 ± 34.51

−9.99 ± 44.39

0.254

(33.539, −26.112)

0.801

1.202

Hippocampal fissurec

25.84(10.07–39.69)

5.07(−16.72 to 39.19)

0.671

(32.633, −13.391)

0.413

1.652

Presubiculumc

4.03(−23.57 to 27.29)

−0.49(−14.00 to 14.41)

0.026

(14.233, −16.780)

0.872

1.046

Parasubiculumb

-2.36 ± 13.45

2.39 ± 14.21

−1.618

(1.722, −14.954)

0.116

0.696

Molecular layer HPb

-20.17 ± 28.72

−22.22 ± 28.94

−0.363

(9.779, −14.008)

0.719

1.233

GC-ML-DGb

−19.13 ± 23.56

−21.54 ± 19.71

−0.014

(9.901, −10.039)

0.989

0.989

CA3b

−14.44 ± 23.47

−15.27 ± 18.58

−0.386

(8.912, −13.078)

0.702

1.404

CA4b

−17.81 ± 22.95

−19.00 ± 18.21

−0.220

(9.246, −11.477)

0.828

1.104

Fimbriab

11.80 ± 12.52

−0.66 ± 24.31

2.343

(25.903, 1.792)

0.026

0.312

HATAd

−0.48 ± 11.08

−0.29 ± 7.27

0.499

(8.397, −5.100)

0.621

1.490

  1. aA general linear model was carried out with the estimated total intracranial volume, age, and gender as the covariate, mean ± SD was used for statistical description.
  2. bA general linear model was carried out with whole hippocampus volume, age, and gender as the covariate, mean ± SD was used for statistical description.
  3. cA generalized linear model was carried out with whole hippocampus volume, age, and gender as the covariate, median (25–75th percentile) was used for statistical description.
  4. dA general linear model was carried out with whole hippocampus volume, baseline HATA volume, age, and gender as the covariate, mean ± SD was used for statistical description. HATA hippocampal amygdala transition area, GC-ML-DG granule cell layer, and molecular layer of the dentate gyrus. The unit of volume is cubic millimeters.
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