Table 2 Outline of the Mendelian randomization analyses performed in this study
Analysis | GWAS | IVs | SNPs p-value threshold | MR-method |
|---|---|---|---|---|
Mendelian Randomization: T2D → OSA | BMI-unadjusted and BMI-adjusted European T2D and OSA GWASs: DIAGRAM, MVP-White | SNPs significantly associated with T2D | 5 × 10−8 10−7 10−5 | Primary: IVW, MR-RAPS, MR-PRESSO Secondary: MR-Egger, weighted median, simple mode, weighted mode, MR-RAPS. |
Mendelian Randomization: OSA → T2D | BMI-unadjusted and BMI-adjusted European T2D and OSA GWASs: DIAGRAM, MVP-White | SNPs significantly associated with OSA | 5 × 10−8 10−7 10−5 | Primary: IVW, MR-RAPS, MR-PRESSO Secondary: MR-Egger, weighted median, simple mode, weighted mode, MR-RAPS. |
Multivariable Mendelian Randomization: T2D → OSA | BMI-unadjusted European T2D, BMI and OSA GWASs: DIAGRAM, GIANT, MVP-White | SNPs significantly associated with T2D or BMI | 5 × 10−8 10−7 10−5 | Primary: IVW |
Multivariable Mendelian Randomization: OSA → T2D | BMI-unadjusted European OSA, BMI and T2D GWASs: DIAGRAM, GIANT, MVP-White | SNPs significantly associated with OSA or BMI | 5 × 10−8 10−7 10−5 | Primary: IVW |
