Table 5 Manual compilation of sex-specific bisphenol A-induced downregulation in females and upregulation in males of T cell-associated differentially expressed genes (DEGs) in combined female BPA(0.5 + 50) and male BPA(0.5 + 50) exposure groups

From: Developmental low-dose bisphenol A exposure leads to extensive transcriptome female masculinization and male feminization later in life

Females, downregulated

T cell Function

Males, upregulated

DEG

BPA

Control

p-value

 

DEG

BPA

Control

p-value

 

Rel. exp.

Rel. exp.

   

Rel. exp.

Rel. exp.

 

Cd28

5.60 ± 0.4

6.10 ± 0.2

0.0171

Formation

Cd2

6.49 ±0.2

5.86 ± 0.4

0.0170

Igf1r

3.56 ± 0.2

4.09 ± 0.3

0.0036

Activation

Cmip

6.00 ± 0.3

5.46 ± 0.1

0.0115

Mr1

6.35 ± 0.2

6.73 ± 0.1

0.0040

 

Foxn1

4.65 ± 0.2

3.92 ± 0.6

0.0314

Nlrp10

5.89 ± 0.3

6.34 ± 0.3

0.0185

 

Gpr65

9.60 ± 0.1

9.31 ± 0.2

0.0217

Tnfrsf11a

3.92 ± 0.4

4.49 ± 0.3

0.0201

 

Igf2r

6.74 ± 0.3

6.09 ± 0.1

0.0078

     

Ikzf1

5.31 ± 0.4

4.65 ± 0.1

0.0266

     

Itk

6.37 ± 0.1

6.04 ± 0.1

0.0113

     

Jaml

4.07 ± 0.6

2.18 ± 1.2

0.0134

     

Lcp2

11.3 ± 0.1

11.0 ± 0.2

0.0425

     

Myo1g

11.0 ± 0.3

10.2 ± 0.7

0.0474

     

Nfatc1

8.51 ± 0.2

8.17 ± 0.1

0.0488

     

Pik3cg

9.48 ± 0.2

9.08 ± 0.2

0.0445

     

RT1-T18

4.88 ± 0.2

4.27 ± 0.4

0.0141

     

Sh2d1a

4.98 ± 0.3

4.36 ± 0.4

0.0218

     

Stam2

10.0 ± 0.2

9.62 ± 0.1

0.0424

     

Tagap

8.94 ± 0.2

8.42 ± 0.4

0.0361

     

Thrap3

5.63 ± 0.2

4.55 ± 0.1

0.0001

     

Tnfrsf9

4.92 ± 0.1

4.50 ± 0.2

0.0054

Crtam

5.67 ± 0.4

6.11 ± 0.2

0.0280

CD4 helper

Cd3g

6.41 ± 0.1

6.06 ± 0.4

0.0442

Il7

3.36 ± 0.5

3.97 ± 0.3

0.0377

1/17 cells

Clec4e

8.12 ± 0.3

7.49 ± 0.4

0.0285

Lag3

4.61 ± 0.3

5.08 ± 0.2

0.0052

 

Ifnlr1

3.63 ± 0.4

2.53 ± 0.7

0.0172

Mapk4

1.36 ± 0.9

2.93 ± 1.6

0.0284

 

Il16

8.31 ± 0.2

7.80 ± 0.4

0.0262

Rora

5.82 ± 0.3

6.26 ± 0.2

0.0142

 

Malt1

8.38 ± 0.2

7.90 ± 0.3

0.0176

Sppl3

5.20 ± 0.3

5.48 ± 0.1

0.0389

 

Map2k6

5.57 ± 0.1

5.33 ± 0.0

0.0130

     

Map3k4

7.38 ± 0.3

6.87 ± 0.3

0.0451

     

Stat4

6.96 ± 0.1

6.61 ± 0.1

0.0005

     

Tnf

5.84 ± 0.3

5.26 ± 0.2

0.0165

Tox2

5.05 ± 0.3

5.51 ± 0.4

0.0164

CD8/

Bhlhe40

8.05 ± 0.3

7.53 ± 0.1

0.0192

Txk

7.26 ± 0.3

7.59 ±0.3

0.0487

Exhausted

Ccl4

4.94 ± 0.1

3.61 ± 1.1

0.0138

     

Ceacam1

10.3 ± 0.1

10.1 ± 0.2

0.0140

     

Clec9a

5.65 ± 0.2

5.19 ± 0.3

0.0245

     

Entpd1

9.41 ± 0.1

8.89 ± 0.4

0.0144

     

Eomes

6.23 ± 0.2

5.54 ± 0.1

0.0021

     

Gpr18

8.27 ± 0.1

7.83 ± 0.3

0.0202

     

Klra5

6.30 ± 0.6

4.54 ± 0.5

0.0026

     

Klrg1

5.92 ± 0.1

5.64 ± 0.2

0.0487

     

Pdcd1

4.85 ± 0.4

4.20 ± 0.3

0.0450

     

Pdcd1lg2

5.32 ± 0.4

4.37 ± 0.3

0.0118

     

Satb1

9.05 ± 0.1

8.73 ± 0.1

0.0088

  1. Average relative expression level (Rel. exp.) is shown as DEG value ± SD. Control female n = 5, control male n = 3, BPA female n = 10, and BPA male n = 6. Student’s t-test.
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