Table 2 Associations of sex specific HFF quartiles with carotid wall volume (mm3) in the CAHHM cohort

From: Visceral adipose tissue and hepatic fat as determinants of carotid atherosclerosis

 

Carotid Wall Volume, mm3 in Hepatic Fat Quartiles

 
 

Q1

Q2

Q3

Q4

P-trend

Overall (n = 5546)

N

1415

1388

1399

1344

 

No fixed covariates

903.2 (882.9, 923.5)

905.3 (884.9, 925.7)

911.8 (891.5, 932.1)

908.0 (887.6, 928.4)

0.29

Minimally adjusted

903.3 (881.8, 924.8)

900.6 (879.0, 922.1)

908.4 (886.9, 929.8)

905.2 (883.7, 926.7)

0.45

+ IHRS

904.0 (882.7, 925.3)

901.2 (879.8, 922.5)

908.0 (886.7, 929.3)

903.3 (881.8, 924.8)

0.81

+VAT

907.2 (885.4, 929.0)

903.2 (881.4, 924.9)

907.6 (886.0, 929.2)

899.0 (876.9, 921.1)

0.36

Minimal + IHRS without WHR

903.5 (882.1, 924.9)

900.7 (879.3, 922.2)

908.1 (886.8, 929.5)

904.4 (882.8, 925.9)

0.59

Females (N = 3054)

N

791

758

777

728

 

No fixed covariates

841.7 (820.1, 863.4)

843.0 (821.2, 864.9)

847.4 (825.7, 869.1)

840.9 (819.1, 862.7)

0.93

Minimally adjusted

845.2 (823.7, 866.8)

843.6 (821.9, 865.3)

845.9 (824.3, 867.5)

839.9 (818.2, 861.6)

0.54

+ IHRS

846.1 (824.7, 867.4)

844.6 (823.1, 866.1)

845.9 (824.6, 867.2)

837.7 (816.1, 859.3)

0.30

+VAT

848.3 (826.7, 870.0)

846.3 (824.5, 868.0)

845.7 (824.3, 867.1)

833.9 (811.5, 856.2)

0.10

Minimal + IHRS without WHR

845.8 (824.4, 867.2)

844.3 (822.7, 865.8)

845.9 (824.5, 867.2)

838.4 (816.7, 860.0)

0.36

Males (N = 2492)

N

624

630

622

616

 

No fixed covariates

974.5 (952.2, 996.9)

971.2 (948.8, 993.5)

984.2 (962.0, 1007)

980.1 (957.7, 1002)

0.32

Minimally adjusted

973.7 (951.7, 995.6)

970.1 (948.2, 992.0)

983.5 (961.6, 1005)

982.0 (960.0, 1004)

0.19

+ IHRS

974.5 (952.5, 996.6)

970.7 (948.7, 992.6)

982.9 (961.1, 1005)

980.5 (958.2, 1003)

0.34

+VAT

979.0 (956.0, 1002)

972.9 (950.4, 995.5)

982.1 (959.7, 1004)

975.6 (952.2, 999.0)

0.98

Minimal + IHRS without WHR

973.7 (951.7, 995.8)

970.2 (948.2, 992.1)

983.6 (961.7, 1005)

982.1 (959.8, 1004)

0.21

  1. Data within each cell are the adjusted least-squared means derived from a mixed model using all participants falling into that sex-specific quartile of VAT. Each mean and (95% confidence interval) is adjusted for the covariates presented in the first column. The minimally adjusted model contains a random effect for centre; as well as fixed effects for age and ethnicity. A linear contrast was used to assess the P-trend, using values of 1–4 across the quartiles. P-sex interaction > 0.41.
  2. VAT visceral adipose tissue, IHRS INTERHEART Risk Score, HFF hepatic fat fraction, WHR waist-to-hip ratio.
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