Table 1 Characteristics of youth with vertical HIV (YWVH) with MASLD (MASLD) or without MASLD (Control)

From: Metabolomics for searching non-invasive biomarkers of metabolic dysfunction-associated steatotic liver disease in youth with vertical HIV

 

MASLD (n = 10)

Control (n = 19)

p-value

Age

20 (10.70–27)

18 (15–24)

0.369

Sex (Women)

6 (60%)

12 (63.2%)

0.868

BMI

23.25 (20.45–25.45)

19 (19–22.50)

0.051

Overweight (BMI > 25)

3 (30%)

1 (5.3%)

0.066

Obesity (BMI > 30)

1 (10%)

0 (0%)

0.161

Glucose (mg/dl)

79.5 (77–86.7)

82 (72–84)

0.730

Triglycerides (mg/dl)

83 (68.75–173.75)

77 (57–137)

0.536

Cholesterol (mg/dl)

171 (136–181.50)

153 (146–174)

0.535

LDL (mg/dl)

102.5 (74.25–117.75)

83 (59.50-96)

0.187

HDL (mg/dl)

43 (36–52.25)

51 (46–56)

0.077

Bilirubin (mg/dl)

0.475 (0.40–59)

0.5 (0.34–16)

0.651

Alanine aminotransferase (ALT) (U/L)

18 (12–24.50)

22 (12–28)

0.475

Aspartate aminotransferase (AST) (U/L)

17.5 (14.50–21)

22 (14–21)

0.231

Gamma-glutamyl transferase (GGT) (U/L)

19 (15–36.50)

17 (14–21)

0.310

Fibro Scan values (Kpa)

5.15 (3.72–6.62)

5 (4.55–5.55)

0.907

Fibrosis-4 score (FIB-4)

0.26 (0.18–0.40)

0.34 (0.24–0.55)

0.172

AST to platelet ratio index (APRI)

0.15 (0.10–0.20)

0.20 (0.20–0.30)

0.040

Hepatic steatosis index (HSI)

33.95 (28.45–39.72)

27.95 (26.87–32.05)

0.017

TyG

4.39 (4.27–4.78)

4.4 (4.22–4.61)

0.520

Viral loads detectable (>50 copies/ml)

0 (0%)

5 (26.3%)

0.075

CD4+ T-cell count

880.50 (670–1442.5)

792.50 (665–1081.75)

0.350

CD8+ T-cell count

820 (685–1101)

814 (519.50–955)

0.402

CD4+/CD8+ T-cell ratio

1.50 (0.94–2.06)

1.20 (0.91–1.57)

0.303

CD4+ T-cell Nadir

296.50 (212–370.50)

443 (310.75–524.5)

0.055

CD4+ T-cells <200 cell/ul

1 (10%)

1 (5.3%)

0.676

Years in ART

17 (9.83–25.73)

15.65 (11.9–22.15)

0.732

Current ART (%)

1 PI (%)

2 (20)

1 (5.3)

0.215

1 PI + 1 INSTI (%)

0 (0)

1 (5.3)

0.460

1 NNRTI + 1 INSTI (%)

1 (10)

1 (5.3)

0.632

2 NRTI + 1 INSTI (%)

3 (30)

10 (52,6)

0.244

2 NRTI + 1 PI (%)

1 (10)

4 (21.1)

0.454

2 NRTI + 1 NNRTI (%)

3 (30)

2 (10.5)

0.187

2 NNRTI + 2 INSTI

0 (0)

0 (0)

1.000

  1. Statistical differences between groups were performed using the χ2 test for categorical data and the non-parametric Mann-Whitney U-test for continuous data according to MASLD development. Data are presented as N (%) or median (25th–75th interquartile range). BMI body mass index, TyG triglycerides and fasting glucose index. TyG Triglycerides and fasting glucose index, PI Protease inhibitor, INSTI integrase strand transfer inhibitors, NNRTI non-nucleoside reverse transcriptase inhibitors and NRTI nucleoside reverse transcriptase inhibitors. The significant p-value is marked in bold.
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