Fig. 4: Regional standardized uptake value ratios (SUVR) and network-based amyloid-β pathology (NAP) maps. | Communications Medicine

Fig. 4: Regional standardized uptake value ratios (SUVR) and network-based amyloid-β pathology (NAP) maps.

From: Integrating individualized connectome with amyloid pathology improves predictive modeling of future cognitive decline

Fig. 4

a Group averaged structural connectome (SC) connectivity-weighted NAP scores. b Correlation coefficient between cognitive decline and SC connectivity-weighted NAP scores across cortical regions of interest (ROIs) (Spearman partial correlation, controlling for age, sex, education, baseline cognition, and hemispherical mean cortical thickness). c Correlation coefficient between cognitive decline and regional SUVR scores across cortical ROIs. NAP scores have higher values in basal cortex regions (a). Individual variability in NAP scores in basal cortex regions and the left dorsolateral prefrontal cortex scales with cognitive decline (b), showing a stronger negative correlation with subsequent cognitive change compared to regional SUVR scores (c). The analysis included seventy-seven participants for whom all data were available.

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