Fig. 2: Tau-PET is strongly associated with CSF YKL-40 in APOE ε4 carriers. | Communications Medicine

Fig. 2: Tau-PET is strongly associated with CSF YKL-40 in APOE ε4 carriers.

From: APOE ε4 potentiates tau related reactive astrogliosis assessed by cerebrospinal fluid YKL40 in Alzheimer’s disease

Fig. 2: Tau-PET is strongly associated with CSF YKL-40 in APOE ε4 carriers.

A Voxelwise linear regression between CSF YKL-40 and tau-PET in APOE ε4 carriers and non-carriers (two-sided, RFT corrected at p < 0.001). Color bar indicates t-values. B Voxelwise linear regression model with interaction between CSF YKL-40 and APOE ε4 status on tau-PET (two-sided) correcting for age, sex and global amyloid-β. Orange shows results of interaction corrected for multiple comparisons (p < 0.001), green shows uncorrected results (p < 0.05). C Tau-PET SUVR controlling for global amyloid-β in regions of interaction displayed in orange, in APOE ε4 carriers and non-carriers, n = 132 (50 APOE ε4 carriers, 82 APOE ε4 non-carriers). Stars show the level of significance of a two-sided Wilcoxon rank-sum test (p = 0.009).

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