Fig. 2: Radiomics and survival analysis for cN0 LUAD patients.

A, B Radiomics feature selection using LASSO logistic regression and C the histogram of Radscore based on the selected features. D ROC curves of the Radscore in four cohorts. E–H The AUCs of clinical, radiomic and combined nomogram models in the E training cohort, F internal validation cohort, G prospective test cohort and H external test cohort. RFS curves according to I pathologic OLM status and J Radscore-predicted OLM status in the prognostic assessment cohort. K Forest plot of multivariate Cox regression analysis (n = 286 biologically independent samples). cN0 clinical N0, LUAD lung adenocarcinoma, LASSO least absolute shrinkage and selection operator, ROC receiver operating characteristic, AUC area under the curve, RFS recurrence-free survival.