Fig. 1: Frequency of pathogenic variants in DNA mismatch repair genes across 23 cancer types and controls.

Patients with pathogenic variants in both MSH2 and MSH6 are indicated as MSH2_MSH6. The number of each cancer patients and controls are described in Table 2. The number of patients with ureteral cancer analyzed in this study was 56, and the number of pathogenic variant carriers is only one for each of the MSH2 and MSH6 genes.