Fig. 5: Heritability enrichment and colocalization with gene expression. | Communications Medicine

Fig. 5: Heritability enrichment and colocalization with gene expression.

From: Cardiovascular measures from abdominal MRI provide insights into abdominal vessel genetic architecture

Fig. 5: Heritability enrichment and colocalization with gene expression.

A Heritability enrichment. Dashed horizontal line at FDR of 0.05. Y-axis: P value of the coefficient of the annotated tissue in a model adjusting for baseline genome features. The top three tissue/cell types are labeled for each IDP. EM esophagus muscularis, O ovary, OPC osteoblast primary cells, SM skeletal muscle. B Colocalisation probabilities associated with changes in gene expression in cardiovascular tissues. H-LV heart left ventricle, H-AA heart atrial appendage, CA coronary artery, AA aortic artery, TA tibial artery. Colocalisations with PP4 > 0.7 are colored.

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