Fig. 5: Mediation analysis diagram illustrating the role of metabolic signatures in the relationship between mental health disorders and MASLD risk. | Communications Medicine

Fig. 5: Mediation analysis diagram illustrating the role of metabolic signatures in the relationship between mental health disorders and MASLD risk.

From: Association between mental health and MASLD molecular insights through metabolomics

Fig. 5: Mediation analysis diagram illustrating the role of metabolic signatures in the relationship between mental health disorders and MASLD risk.The alternative text for this image may have been generated using AI.

The model tests whether metabolic alterations mediate the association between mental health exposures (anxiety, depression, mania, trauma) and MASLD. Percentages indicate the proportion of the total effect mediated by metabolic pathways. All indirect effects were statistically significant (P < 0.05).

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