Fig. 6: Disease severity endotypes in lesional skin are largely independent of biologic drug. | Communications Medicine

Fig. 6: Disease severity endotypes in lesional skin are largely independent of biologic drug.

From: Transcriptomic profiling and machine learning uncover gene signatures of psoriasis endotypes and disease severity

Fig. 6: Disease severity endotypes in lesional skin are largely independent of biologic drug.

a Workflow: non-linear (natural-spline 3 d.f.) regression was used to relate gene expression to PASI separately in adalimumab and ustekinumab cohorts; significant genes (q < 0.05) were combined for downstream analysis. b Venn diagram summarising the overlap of significant genes between treatment arms. c Volcano plot for the pooled dataset showing –log10 q versus signed fit range (difference between maximum and minimum fitted expression across the PASI span; sign reflects direction). Left panel colours genes by WGCNA module, right by ICA factor; exemplar genes are annotated. d Example turquoise- and blue-module genes plotted as log2-CPM versus PASI with spline fits. Curves represent natural-spline fits (3 d.f.) with 95% confidence intervals for the predicted values. e Network view (Ingenuity Pathway Analysis): circles = genes (module-coloured), yellow squares = predicted upstream regulators, blue squares = enriched canonical pathways. ADA adalimumab, UST ustekinumab; others as before.

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