Fig. 5: Sex-specific disease–drug associations.
From: Sex-specific transcriptome similarity networks elucidate comorbidity relationships
The nodes represent diseases, colored according to the disease category (ICD-10) to which they belong. An edge connects two diseases if the drug indicated to treat one disease (source node) is enriched in the differential expression profile of another disease (sink node). Only associations between comorbid diseases9 from different ICD-10 categories are shown. The name of the drug connecting both diseases is indicated below the edge. Only associations detected exclusively in one sex are shown, with red (blue) edges denoting associations detected only in females (males). Solid (dashed) lines indicate that the normalized enrichment score of the GSEA28 is positive (negative), for all other associations see https://disease-perception.bsc.es/shdc/ and Supplementary Fig. 9. The network’s visualizations have been generated using Cytoscape software112.
