Table 2 Interactions between genetic risk and early life nutrition for total behaviour problems
ADHD PGS (27 SNPs) | Depression PGS (95 SNPs) | Chronic multisite pain PGS (36 SNPs) | Total problems * (1 SNP) | Birth weight PGS (146 SNPs) | |
|---|---|---|---|---|---|
Breastfeeding N = 1393 O = 7191 | |||||
Breastfeeding duration (0–38 months) | B: −0.0759 SE: 0.0267 CI: [−0.127, −0.0229] P: 0.004 | B: −0.0761 SE: 0.0262 CI: [−0.128, −0.0251] P: 0.004 | B: −0.0801 SE: 0.0270 CI: [−0.133, −0.0268] P: 0.003 | B: −0.0496 SE: 0.0412 CI: [−0.128, 0.0336] P: 0.23 | B:−0.0759 SE: 0.0262 CI: [−0.128, −0.0252] P: 0.004 |
Polygenic score (SD) | B:−0.177 SE: 0.269 CI: [−0.689, 0.366] P: 0.51 | B: 0.0427 SE: 0.274 CI: [−0.497, 0.575] P: 0.88 | B: 0.633 SE: 0.292 CI: [0.0449, 1.19] P: 0.03 | B: 0.579 SE: 0.576 CI: [−0.517, 1.74] P: 0.31 | B: −0.0225 SE: 0.279 CI: [−0.579, 0.514] P: 0.94 |
Interaction | B:0.0324 SE: 0.0263 CI: [−0.0201, 0.0829] P: 0.90 | B: 0.000436 SE: 0.0263 CI: [−0.0505, 0.0525] P: 0.99 | B: −0.0590 SE: 0.0276 CI: [−0.111, −0.00269] P: 0.03 | B: −0.0433 SE: 0.0508 CI: [−0.147, 0.0523] P: 0.39 | B: 0.0216 SE: 0.0247 CI: [−0.0265, 0.0703] P: 0.94 |
Year 1 diet N = 1310 O = 6780 | |||||
EAT1-score (0–70 points) | B: −0.0758 SE: 0.0193 CI: [−0.114, −0.0378] P: 0.00009 | B:−0.0748 SE: 0.0197 CI: [−0.113, −0.0358] P: 0.0001 | B: −0.0752 SE: 0.0198 CI: [−0.114, −0.0358] P: 0.0002 | B: −0.105 SE: 0.034 CI: [−0.171, −0.0379] P: 0.002 | B: −0.0729 SE: 0.0197 CI: [−0.111, −0.0342] P: 0.0002 |
Polygenic score (SD) | B: −2.69 SE: 0.800 CI: [−4.21, −1.07] P: 0.0008 | B: 0.956 SE: 0.936 CI: [−0.878, 2.79] P: 0.3 | B: 0.0130 SE: 0.72 CI: [−1.41, 1.41] P: 0.99 | B:−2.09 SE: 1.763 CI: [−5.54,1.37] P: 0.24 | B: 1.26 SE: 0.831 CI: [−0.375, 2.88] P: 0.13 |
Interaction | B: 0.0625 SE: 0.018 CI: [0.0264, 0.0967] P: 0.0005 | B: −0.0198 SE: 0.0212 CI: [−0.0614, 0.0218] P: 0.35 | B: 0.00498 SE: 0.0162 CI: [−0.0266, 0.0369] P: 0.76 | B:0.0456 SE: 0.0398 CI: [−0.0330, 0.123] P: 0.25 | B: −0.0259 SE: 0.0189 CI: [−0.0629, 0.0113] P: 0.17 |
