Table 3 Behavioural specificity of nutrition association

From: Nutrition in early life interacts with genetic risk to influence preadult behaviour in the Raine Study

 

Total problems

Externalising

Internalising

 

Diet effects by genetic ADHD risk

  

 B EAT-score age 1 (points)

Low genetic risk

(n = 794 O = 4114)

B: −0.121

SE: 0.0258

CI: [−0.171, −0.0704]

P: 0.000003

B: −0.103

SE: 0.0244

CI: [−0.150, −0.0541]

P: 0.00002

B: −0.0861

SE: 0.0229

CI: [−0.131, −0.0410]

P: 0.0002

 B EAT-score age 1 (points)

High genetic risk

(n = 516 O = 2666)

B: −0.0116

SE: 0.0302

CI: [−0.0718, 0.0465]

P: 0.7

B: 0.00148

SE: 0.0281

CI: [−0.0539, 0.0564]

P: 0.96

B: −0.0242

SE: 0.0276

CI: [−0.0799, 0.0285]

P: 0.38

 Interaction: EAT score by continuous ADHD-PGS

(N = 1310 O = 6780)

Primary outcome—See Table 2

B: 0.0560

SE: 0.0163

CI: [0.0236, 0.0876]

P: 0.0006

B: 0.0392

SE: 0.0158

CI: [0.00676, 0.0688]

P: 0.013

Breastfeeding effects by genetic chronic multisite pain risk

 Breastfeeding (months)

Low genetic risk

(n = 669, o = 3458)

B: −0.0486

SE: 0.0355

CI: [−0.120, 0.0193]

P: 0.17

B: −0.0259

SE: 0.0335

CI: [−0.0921, 0.0390]

P: 0.44

B: −0.0604

SE: 0.0321

CI: [−0.124, 0.00174]

P: 0.02

 Breastfeeding (months)

High genetic risk

(n = 724 o = 3733)

B: −0.108

SE: 0.0397

CI: [−0.184, −0.0289]

P: 0.007

B: −0.124

SE: 0.0380

CI: [−0.197, −0.0476]

P: 0.001

B: −0.0770

SE: 0.0350

CI: [−0.144, −0.00710]

P: 0.028

 Interaction: breastfeeding by continuous CMSP-PGS

(n = 1393 O = 7191)

Primary outcome—See Table 2

B: −0.0816

SE: 0.0260

CI: [−0.131, −0.0291]

P: 0.002

B: −0.0192

SE: 0.0236

CI: [−0.0637, 0.0288]

P: 0.42

  1. Exploring different behaviours following cohort stratification. All models adjusted for sex, age at assessment, maternal age at birth, maternal education length, family income, gestational duration, civil status and principal components. Confidence interval (CI) and p-value in mixed models based on bootstrapped standard errors (SE) and two-sided z-test.