Table 1 Baseline characteristics and pregnancy outcomes of the study population

From: Risk of congenital malformation in newborns from mothers with kidney diseases in a nationwide cohort study

Characteristic

Healthy (n = 713,776)

CKD (n = 69,648)

ESKD (n = 311)

Maternal factors

   

Age, y

31.9 ± 3.53

32.3 ± 3.99

33.5 ± 4.22

<25

10,007 (1.3%)

1596 (2.3%)

7 (2.3%)

25–29

166,213 (21.2%)

15,082 (21.7%)

30 (9.7%)

30–34

388,112 (49.5%)

33,606 (48.3)

154 (49.5%)

35–39

131,685 (16.8%)

16,444 (23.6%)

97 (31.2%)

≥40

17,759 (2.3%)

2920 (4.2%)

23 (7.4%)

Maternal comorbidity

   

Hypertension

11,426 (1.6%)

3468 (4.9%)

175 (56.3%)

Diabetes mellitus

19,229 (2.7%)

6794 (9.8%)

117 (37.6%)

Dyslipidemia

64,348 (9.0%)

18,569 (26.66%)

201 (64.6%)

Serum creatinine (mg/dL)

0.79 ± 0.88

0.80 ± 0.95

1.45 ± 1.59

Urine albuminuria (≥1+)

5472 (0.8%)

2448 (4.6%)

18 (16.5%)

Parity (Number of births), n (%)

   

1

487,477 (68.3)

47,098 (67.62)

249 (80.06)

≥2

226,299 (31.7)

22,550 (32.38)

62 (19.94)

Family Income level, n (%)

   

5th Quintile (Highest)

59,371 (8.3%)

8511 (12.2%)

69 (22.2%)

4th Quintile

110,040 (15.4%)

11,488 (16.5%)

49 (15.8%)

3rd Quintile

201,621 (28.3%)

17,912 (25.7%)

71 (22.8%)

2nd Quintile

216,601 (30.4%)

19,079 (27.4%)

56 (18.0%)

1st Quintile (Lowest)

84,936 (11.9%)

9412 (13.5%)

45 (14.5%)

Urbanity, n (%)

   

Urban

499,557 (69.9%)

50,193 (72.1%)

213 (68.5%)

Rural

214,219 (30.0%)

19,455 (27.9%)

98 (31.5%)

Neonatal outcomes

   

Neonatal sex, male

366,610 (51.4%)

35,609 (51.1%)

151 (48.6%)

Mean birth weight (kg)

3.21 ± 0.46

3.20 ± 0.48

2.60 ± 0.69

Low birth weight, n (%)

22,707 (3.3%)

2924 (4.3%)

102 (34.6%)

NICU admission

31,613 (4.4%)

3710 (5.3%)

80 (25.7%)

  1. Data are presented as numbers (%) or mean ± Standard deviation (SD).
  2. BMI body mass index, NICU neonatal intensive care unit, CKD chronic kidney disease, ESKD end-stage kidney disease.