Fig. 6: Assessing the role of modules in ADs and functional analysis for each module. | Communications Medicine

Fig. 6: Assessing the role of modules in ADs and functional analysis for each module.

From: Identifying genetic and cellular connections and distinctions among 15 autoimmune diseases using an in-silico approach

Fig. 6: Assessing the role of modules in ADs and functional analysis for each module.The alternative text for this image may have been generated using AI.

A GSEA was performed on the ranked gene list for each AD. The top 10 gene sets (modules) with positive Normalized Enrichment Scores (NES) for each disease are shown, where the dot size represents the number of genes enriched per term. B Pathway enrichment analysis for each module was conducted using KEGG, Reactome, Wikipathways and GO biological process databases via g:profiler. The number of drugs in clinical trials (phases III and IV, ChEMBL) and their respective targets are listed for each module.

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