Fig. 7: Shared and specific modules of ADs. | Communications Medicine

Fig. 7: Shared and specific modules of ADs.

From: Identifying genetic and cellular connections and distinctions among 15 autoimmune diseases using an in-silico approach

Fig. 7: Shared and specific modules of ADs.The alternative text for this image may have been generated using AI.

A Module C1 contains genes in the MHC region. Node colors indicate the number of diseases associated with each gene. Central nodes have the highest degree and closeness centrality scores. B Module C7 is enriched for CD4 + T helper cell differentiation. Drugs in phase IV clinical trials (ChEMBL) and their targets are denoted with rhombuses and squares, respectively. C Module C16 is enriched for complement and coagulation cascades, as well as B cell-mediated immunity, and exhibits high importance specifically for SLE. D Module C8 is enriched for keratinization and epithelial cell differentiation, showing high specificity for PV. All modules were visualized in Cytoscape.

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