Abstract
Background
Timely vaccination effectively reduced COVID-19 hospitalizations and mortality, yet vaccination hesitancy undermined this benefit. Understanding the factors contributing to hesitancy is critical for improving future pandemic control by identifying barriers to timely vaccination. This paper operationalizes hesitancy in terms of vaccine delay—a key public health metric that reflects changing vaccination policies and infection status, factors that can alter individuals’ eligibility, and real-world complexities like infections.
Method
Using longitudinal data from the earliest stage of the pandemic in Hong Kong, we examined how institutional trust and the 5C constructs (confidence, complacency, constraints, calculation, and collective responsibility) influenced both vaccination intention and timing.
Results
Our results show that only 34.89% and 42.97% of vaccinated participants received their first and third doses within 100 days of eligibility, respectively, despite rising uptake prior to government mandates. Confidence and vaccination intention are key predictors of delay, and higher institutional trust boosts both confidence and collective responsibility, thereby enhancing intention and reducing delays.
Conclusions
These findings underscore the importance of building institutional trust and public confidence to minimize vaccine delay, particularly among vulnerable populations. Ultimately, incorporating vaccine delay as a key metric into public health strategies can guide more effective interventions and strengthen pandemic preparedness.
Plain language summary
Vaccination against COVID-19 has prevented many hospitalizations and deaths, yet delays in getting vaccinated have limited these benefits. We examined why people in Hong Kong postponed vaccination and proposed vaccination delay as an important metric for understanding vaccine hesitancy and rollout success. Using repeated survey data collected during the pandemic, we analyzed how trust in health authorities and psychological factors—such as confidence, perceived barriers, and social responsibility—affected both vaccination intention and timing. We found that higher trust and confidence were linked to earlier vaccination. Recognizing vaccination delay as a key public health measure can help governments design strategies that build trust, encourage timely uptake, and improve preparedness for future pandemics.
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Acknowledgements
We would like to acknowledge support from the Health and Medical Research Fund (reference numbers: INF-CUHK-1, 17160302, 18170312, CID-CUHK-A, COVID1903008), General Research Fund (reference numbers: 14112818, 24104920), Wellcome Trust Fund (reference number: 200861/Z/16/Z), Group Research Scheme and Funding Allocation to Faculties by Research Committee and Inbound Mobility Scheme (OAL) of The Chinese University of Hong Kong. A.T. acknowledges the support from the RMIT Vietnam Strategic Innovation Challenge.
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K.O.K. is an Editorial Board Member for Communications Medicine but was not involved in the editorial review or peer review, nor in the decision to publish this article. Other authors declare no competing interests.
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Leung, C.L.K., Li, KK., Tang, A. et al. Institutional trust and vaccination delay as key metrics for vaccination rollout success. Commun Med (2026). https://doi.org/10.1038/s43856-026-01597-4
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DOI: https://doi.org/10.1038/s43856-026-01597-4


