Extended Data Fig. 7: Fed-batch fermentation profiles of methanol concentration, dissolved oxygen (DO), and pH after induction.
From: Biosynthesis of catharanthine in engineered Pichia pastoris
Fed-batch fermentation profiles of methanol concentration, dissolved oxygen (DO), and pH after induction. Methanol (a) or methanol/mannitol (b) was fed into the bioreactor as carbon sources for fermentative production of catharanthine. After induction for 30 h, 100 mL 5-fold concentrated YPA medium was supplemented to the bioreactors as additional nitrogen source.
