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Chemoenzymatic synthesis

Enzymes on steroids

Nature Synthesis volume 2, pages 699–700 (2023)Cite this article

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Assembly and functionalization of biologically active steroids continue to pose a synthetic challenge. Now, mining and engineering of selective P450 C–H hydroxylases provide a biocatalytic C14–H hydroxylation, which can be integrated into chemoenzymatic syntheses of C14-functionalized steroids.

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Fig. 1: Chemoenzymatic synthesis of C14-functionalized steroids.

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Authors and Affiliations

  1. Department of Chemistry and Biochemistry, University of California Santa Barbara, Santa Barbara, CA, USA

    Liupeng Zhao, Zhiyu Bo & Yang Yang

  2. Biomolecular Science and Engineering (BMSE) Program, University of California Santa Barbara, Santa Barbara, CA, USA

    Yang Yang

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  1. Liupeng Zhao
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  2. Zhiyu Bo
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  3. Yang Yang
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Correspondence to Yang Yang.

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Zhao, L., Bo, Z. & Yang, Y. Enzymes on steroids. Nat. Synth 2, 699–700 (2023). https://doi.org/10.1038/s44160-023-00287-6

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