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Asymmetric catalysis

Selective cross-hydrodimerization of alkenes

Enantioenriched alkyl–alkyl bonds are produced from abundant alkenes in one step via Ni-catalysed asymmetric cross-hydrodimerization. This technique overcomes the reactivity and selectivity challenges associated with coupling between two similar nucleophiles.

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Fig. 1: Reaction modes for metal-catalysed asymmetric alkyl–alkyl bond-forming processes.

References

  1. Lin, G.-Q., You, Q.-D. & Cheng, J.-F. (eds) Chiral Drugs: Chemistry and Biological Action (Wiley, 2011).

  2. Lovering, F., Bikker, J. & Humblet, C. J. Med. Chem. 52, 6752–6756 (2009).

    Article  CAS  PubMed  Google Scholar 

  3. Cherney, A. H., Kadunce, N. T. & Reisman, S. E. Chem. Rev. 115, 9587–9652 (2015).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  4. Wang, Z., Yin, H. & Fu, G. C. Nature 563, 379–383 (2018).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  5. Zhao, W.-T. & Shu, W. Sci. Adv. 9, eadg9898 (2023).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  6. Yang, P.-F., Zhao, H.-T., Chen, X.-Y. & Shu, W. Nat. Synth. https://doi.org/10.1038/s44160-024-00609-2 (2024).

    Article  PubMed  Google Scholar 

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Correspondence to Debabrata Maiti.

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Maiti, S., Maiti, D. Selective cross-hydrodimerization of alkenes. Nat. Synth 3, 1320–1321 (2024). https://doi.org/10.1038/s44160-024-00635-0

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