Fig. 5: Reactions of alkyllithiums and Barbier-type reactions. | Nature Synthesis

Fig. 5: Reactions of alkyllithiums and Barbier-type reactions.

From: Mechanochemical activation of metallic lithium for the generation and application of organolithium compounds in air

Fig. 5

a, One-pot two-step protocol (primary alkyllithium species). b, Barbier-type reaction (phenyl, primary, secondary and tertiary alkyllithium species, as well as vinyllithium species and heteroaryllithium species). Isolated yields are shown. Integrated 1H NMR spectroscopic yields are shown in parentheses. See Supplementary Section 2 for details. E+, electrophile.

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