Organosodium reagents have long been considered too reactive for application in organic synthesis. Now, sodium-based nucleophiles can be used with iron catalysis to enable C(sp2) homo-coupling and C(sp2)–C(sp3) cross-coupling reactions.
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Briggs-Pritchard, J., Neidig, M.L. Coupling reactions using iron–sodium pairs. Nat. Synth 4, 783–784 (2025). https://doi.org/10.1038/s44160-025-00779-7
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DOI: https://doi.org/10.1038/s44160-025-00779-7
