Fig. 5: MI leads to integrin activation and vascular permeability in the bone marrow.
From: Bone marrow endothelial dysfunction promotes myeloid cell expansion in cardiovascular disease
a, In vivo precontrast T2-weighted rapid acquisition with refocused echoes (RARE) MRI (left), post-contrast parametric map of the permeability surface area product (MRI permeability, middle) and three-dimensional (3D) PET–computed tomography (CT) of 68Ga-RGD uptake in the femur (right). b, 68Ga-RGD PET–CT fused with MRI parametric permeability maps. In vivo mean permeability (c) and PET standardized uptake value (SUV) (d) (n = 6 control mice, n = 4 with MI, two-tailed Mann–Whitney test). e, 68Ga-RGD autoradiography of femora. f, Scintillation counting of femora yielding percent injection dose per g tissue (IDGT) (n = 7 control mice, n = 10 for MI, two-tailed Mann–Whitney test). g, Post-MI 68Ga-RGD uptake in different bone marrow locations normalized to that in the control (n = 9 mice for all, two-sided Friedman test with Dunn’s post-test). Data are displayed as mean ± s.e.m.
