Extended Data Fig. 5: INU1-fab induced platelet consumption and mortality strictly require platelet CLEC-2/ITAM signaling.
a. Mortality following INU1-fab (0.5 µg/g i.v.) challenge was monitored in the indicated groups. WT n = 14, all other groups n = 10, biologically independent. b. Platelet counts were determined 20 min after INU1-fab treatment of the depicted mice using flow cytometry. The results are depicted in a box whisker blot with the central line representing the median and the whiskers indicating minimum and maximum. WT n = 13, mutant and CLEC-2 depleted mice n = 5, platelet-depleted n = 10, biologically independent.
