Extended Data Fig. 3: Generality of INa,L regulation by FHF1A. | Nature Cardiovascular Research

Extended Data Fig. 3: Generality of INa,L regulation by FHF1A.

From: Fibroblast growth factor homologous factors serve as a molecular rheostat in tuning arrhythmogenic cardiac late sodium current

Extended Data Fig. 3

a, Schematic illustrates the α-subunit of NaV1.5 channel showing missense (grey) and nonsense (red) mutations in disparate channel domains. b, Exemplar multichannel recordings of NaV1.5 F1759A in the absence (top) and presence of FHF1A (bottom). c-f. Exemplar recordings suggests that FHF1A inhibits E[1784]K, S[1904]L, Q[1909]R, and Δ1885 mutant.

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