Extended Data Table 2 Early markers of LVH induction in response to left ventricular pressure overload in WTLs and Piezo1P1-tdT/P1-tdT mice. Relative mRNA expression of ANP (Nppa), BNP (Nppb) and α-SA (Acta1) in LV tissue and cardiomyocytes (CMs) 2 days and 14 days after TAC compared to sham (n = 3–5/group). The relative mRNA expression was normalized with GAPDH and calculated as fold change relative to sham in 2 days and 14 days groups, respectively. Results are presented as mean ± SEM, two-way ANOVA with Tukey’s post-hoc test for multiple comparisons was used to assess effects of genotype, surgery, and genotype by surgery interaction *p < 0.05, **p < 0.01, ***p < 0.001 vs sham-operated groups for the respective genotype
