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Inhibitory immune checkpoints cause exhaustion of viral immunity in coronary artery disease

Nature Cardiovascular Research volume 1, pages 607–608 (2022) Cite this article

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In patients with coronary artery disease, stabilizing post-translational modifications to the mRNA of the immune-checkpoint inhibitor CD155 result in an immunosuppressive macrophage phenotype and impair activation of T cells in response to viral infection.

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Fig. 1: Immunosuppressive macrophages in CAD.
The alternative text for this image may have been generated using AI.

References

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This is a summary of: Zhao, T. V. et al. Hyperactivity of the CD155 immune checkpoint suppresses anti-viral immunity in patients with coronary artery disease. Nat. Cardiovasc. Res. https://doi.org/10.1038/s44161-022-00096-8 (2022).

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Inhibitory immune checkpoints cause exhaustion of viral immunity in coronary artery disease. Nat Cardiovasc Res 1, 607–608 (2022). https://doi.org/10.1038/s44161-022-00103-y

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