Extended Data Fig. 2: Integrative transcriptional and chromatin accessibility analysis identifies putative key cardiac regulators.
From: Human-gained heart enhancers are associated with species-specific cardiac attributes
a, Dot plot shows expression (circle color) and transcription factor motif enrichment (circle size) of known and potential novel regulators of human ventricle cardiomyocyte differentiation. b, Heatmap shows differentially regulated super-enhancers during cardiomyocyte differentiation. c, Distribution of H3K27ac signal for each of the indicated stages shows super-enhancer loci with associated genes of interest based on proximity. PSC, pluripotent stem cells; Mes, mesoderm; Cmes, cardiac mesoderm; CP, cardiac progenitor; CM, cardiomyocyte; vCM, ventricular cardiomyocyte; FPKM, fragments per kilobase of transcript per million mapped reads.
