Extended Data Fig. 1: (a-b) Left ventricle internal dimension and wall thickness in TAC and Sham groups determined by echocardiography four weeks post-surgery. | Nature Cardiovascular Research

Extended Data Fig. 1: (a-b) Left ventricle internal dimension and wall thickness in TAC and Sham groups determined by echocardiography four weeks post-surgery.

From: Mitochondrial interactome quantitation reveals structural changes in metabolic machinery in the failing murine heart

Extended Data Fig. 1

(c-d) Lung and liver edema (wet weight/dry weight in mg) measured at tissue harvest. (e) Quantitation of mean cross-link (XL) ratio vs mean dead-end (DE) ratio for each cross-linked peptide pair statistically changed in TAC in at least 4/6 biological pairs (Log2 TAC/Sham). The sum of the Mean DE ratio for Protein A and Protein B is shown to account for cross-links between two different proteins. (f) Interaction network of lysine residues (black nodes) connected by observed cross-links (edges). Edges are colored according to increasing (red) and decreasing (blue) quantitation of statistically significant subset of cross-links (Log2 TAC/Sham) shown by color scale. For (a-d), all data are n=12 animals, AVG+/-SEM, *denotes p<0.05 by unpaired, two-tailed Student’s t-test.

Back to article page