Extended Data Fig. 10: Flecainide induces partial IK1 rectification in HEK293 cells. | Nature Cardiovascular Research

Extended Data Fig. 10: Flecainide induces partial IK1 rectification in HEK293 cells.

From: Kir2.1 dysfunction at the sarcolemma and the sarcoplasmic reticulum causes arrhythmias in a mouse model of Andersen–Tawil syndrome type 1

Extended Data Fig. 10

Left, current-voltage (I-V) relationships constructed at the end of the test pulses for IK1 with (black, as maximum rectification) and without (grey, as control) polyamine rectification, and after 10 µM flecainide block (red) (P < 0.0001 for voltages ≤ −90mV; P = 0.0003, for −80mV; P = 0.0113, for −70mV; P = 0.0342, for −60mV). Right, graphs show the normalized current at −40mV (P = 0.0013, IK1 vs IK1 without rectification; P = 0.0413, IK1 vs IK1 without rectification + flecainide; and, P = 0.0154, IK1 without rectification vs IK1 without rectification + flecainide). Each value is represented as mean ± SEM. Statistical analyses were conducted using Two-way ANOVA and One-way ANOVA test, respectively. *, p < 0.05; **, p < 0.01; ***, p < 0.001; ****, p < 0.0001.

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