Extended Data Fig. 1: Unsupervised clustering of plaques based on transcriptomics data.

a) PCA plot and b) tSNE projection of the 654 plaque samples based on RNA-seq dataset. The color indicates the cluster corresponding to the plaque type cluster from the SNN modularity optimization based clustering algorithm. c) Distribution of non-ribosomal protein-coding genes with annotated HGNC name; reads mapping to mitochondrial genes and mean Pearson correlation of samples per cluster