Table 2 Diagnoses within 90 days of exposure for study sample with documented SARS-CoV-2 infection (n = 12,460)

From: Apparent risks of postural orthostatic tachycardia syndrome diagnoses after COVID-19 vaccination and SARS-Cov-2 Infection

Diagnosis

No. new diagnoses

New diagnosis before exposure

New diagnosis after exposure

Post-exposure risk

Diagnostic group

n (per 100,000)

n (per 100,000)

n (per 100,000)

Odds (95% CI)

P value

Diabetes mellitus

328 (2,632.42)

86 (690.21)

242 (1,942.22)

2.81 (2.19–3.63)‡

<0.001

CPC

POTS

383 (3,073.84)

123 (987.16)

260 (2,086.68)

2.11 (1.70–2.63)‡

<0.001

POTS

Hypertension

642 (5,152.49)

216 (1,733.55)

426 (3,418.94)

1.97 (1.67–2.33)‡

<0.001

CPC

Iron deficiency anemia

125 (1,003.21)

45 (361.16)

80 (642.05)

1.78 (1.22–2.60)†

0.002

CPC

Hyperlipidemia

244 (1,958.27)

91 (730.34)

153 (1,227.93)

1.68 (1.29–2.20)‡

<0.001

CPC

UTI

438 (3,515.25)

167 (1,340.29)

271 (2,174.96)

1.62 (1.33–1.98)‡

<0.001

CPC

Anxiety

211 (1,693.42)

83 (666.13)

128 (1,027.29)

1.54 (1.16–2.05)†

0.002

CPC

Depression

108 (866.77)

43 (345.10)

65 (521.67)

1.51 (1.01–2.26)*

0.043

CPC

Myocarditis

5 (40.13)

2 (16.05)

3 (24.08)

1.50 (0.21–12.78)

1.00

Myocarditis

Dizziness

167 (1,340.29)

72 (577.85)

95 (762.44)

1.32 (0.96–1.81)

0.09

CPC

Fatigue

619 (4,967.90)

275 (2,207.06)

344 (2,760.83)

1.25 (1.06–1.47)†

0.006

POTS

GERD

160 (1,284.11)

74 (593.90)

86 (690.21)

1.16 (0.84–1.60)

0.39

CPC

Edema

107 (858.75)

51 (409.31)

56 (449.44)

1.10 (0.74–1.63)

0.70

CPC

Lumbago

192 (1,540.93)

95 (762.44)

97 (778.49)

1.02 (0.76–1.37)

0.94

CPC

Dysautonomia

2 (16.05)

1 (8.03)

1 (8.03)

1.00 (0.10–9.58)

1.00

POTS

Cellulitis

98 (786.52)

56 (449.44)

42 (337.08)

0.75 (0.49–1.14)

0.19

CPC

Eczema

98 (786.52)

56 (449.44)

42 (337.08)

0.75 (0.49–1.14)

0.19

CPC

Headache

407 (3,266.45)

249 (1,998.39)

158 (1,268.06)

0.63 (0.52–0.78)‡

<0.001

CPC

EDS

0 (0)

0 (0)

0 (0)

–

–

POTS

Mast cell disorders

0 (0)

0 (0)

0 (0)

–

–

POTS

  1. CI, confidence interval; GERD, gastroesophageal reflux disease.
  2. Odds of post-exposure diagnosis were estimated using one-sample proportions testing with continuity correction, and two-sided P values are shown without correction for multiple testing while noting that a conservative Bonferroni threshold of 0.05/20 = 0.0025 may be considered for aiding interpretation of results.
  3. *P < 0.05, †P < 0.01, ‡P < 0.001
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