Fig. 1: Elevated plasma IGFBP in HF is correlated with chronic inflammation and accelerated cellular senescence.
From: Insulin-like growth factor-binding protein-7 (IGFBP7) links senescence to heart failure
a, IGFBP7 and NT-proBNP protein concentrations in plasma samples of patients with HFpEF (n = 106), patients with HFrEF (n = 207) and controls (n = 98) are presented as mean ± s.e.m. in scatter plots; one-way ANOVA with Bonferroni correction for multiple comparisons was used to calculate P value. b, ROC curve shows that the addition of IGFBP7 to NT-proBNP II values significantly improved the diagnostic performance in the discrimination of HFpEF from HFrEF. c, Correlation analysis revealed that increased plasma IGFBP7 level in HFpEF correlates with decreased diastolic function of the heart. d, Heat map shows changes of SASP proteins in plasma samples of HFpEF (n = 13), HFrEF (n = 26) and controls (HC) (n = 9); protein expression is shown as fold change against control group. P < 0.05–0.0001 for all panels. e, Relative gene expression of key senescence markers in whole blood samples; CDKN2A (p16), CDKN1A (p21) and TP53 (p53) are shown as fold changes against HC (n = 15 per group). Error bars represent s.e.m. One-way ANOVA with Bonferroni correction for multiple comparisons was used to calculate P values. RA, right atrial; RVSP, right ventricular systolic pressure.
