Extended Data Fig. 9: Distinct transcriptional profiles in human hearts affected by dilated cardiomyopathy.
From: KDM8 epigenetically controls cardiac metabolism to prevent initiation of dilated cardiomyopathy
a, Principal component (PC) analysis plot displaying separation of the transcriptome of healthy human hearts or affected by end-stage dilated cardiomyopathy (DCM). The separation in PC2 is attributed to sex based on the level of transcripts expressed from X and Y chromosomes like XIST and RPS4Y1 respectively. b, Violin plots of normalized mRNA levels of KDM8 and c, NAMPT in control and DCM-affected human hearts. n = 47 female controls, 66 male controls, 29 female DCM-affected, and 120 male DCM-affected. d, Violin plots of normalized mRNA levels of TBX15 in control, MitoMild and MitoSevere. n = 47 female controls, 66 male controls, 24 female MitoMild, 106 male MitoMild, 5 female MitoSevere, and 14 male MitoSevere. b-d, Thick dotted lines denote the median. Thin dotted lines denote the quartiles. Data was analyzed by two-way ANOVA and Sidak correction for multiple comparisons.
