Fig. 3: Tolerance phenotypes at the level of transcripts in non-expanded versus expanded plaque CD8+ and CD4+ effector/memory cells. | Nature Cardiovascular Research

Fig. 3: Tolerance phenotypes at the level of transcripts in non-expanded versus expanded plaque CD8+ and CD4+ effector/memory cells.

From: Pairing of single-cell RNA analysis and T cell antigen receptor profiling indicates breakdown of T cell tolerance checkpoints in atherosclerosis

Fig. 3: Tolerance phenotypes at the level of transcripts in non-expanded versus expanded plaque CD8+ and CD4+ effector/memory cells.

a,b, Dot plots of gene expression profiles of selected tolerance-associated genes in CD8+ Teff/mem cells. Genes related to T cell egress/residency (Ccr7, S1pr1, Sell), activation/migration (Cxcr6, Ccr5, Slamf7, Adgre5, S100a4, S100a6, Ctsw), cytotoxicity/cytokines (Cst7, Gzmb, Gzmk, Gzmm, Ifng, Nkg7, Prf1, Efhd2, Ccl5, Ccl4); genes related to exhaustion-associated surface receptors (Pdcd1, Tigit, Lag3, Havcr2), exhaustion-related signaling molecules (Ptpn6, Ptpn11, Ptpn2) and exhaustion-related transcription factors (Irf4, Nr4a1, Gata3, Tox, Batf, Prdm1, Eomes) are listed in b. Non-expanded and expanded CD8+ Teff/mem cells obtained from WT RLNs, Apoe−/− RLNs, ATLOs and plaques are compared. c,d, Dot plots of gene expression levels of selected function-associated genes in CD4+ Teff/mem cells. Genes related to T cell egress/residency (Ccr7, S1pr1, Sell), activation/migration (Cxcr6, Ccr5, Slamf7, Adgre5, S100a4, S100a6, H2-D1), transcription factors and cytokines (Ifng, Lta, Tbx21, Il5, Il4, Il13, Gata3, Il17a, Rorc) are listed in c; genes related to exhaustion surface receptors (Pdcd1, Tigit, Lag3, Ctla4), exhaustion signaling molecules (Ptpn6, Ptpn11, Ptpn2) and exhaustion transcription factors (Irf4, Nr4a1, Gata3, Tox, Batf, Prdm1, Eomes) are listed in d. Non-expanded and expanded CD4+ Teff/mem cells obtained from WT RLNs, Apoe−/− RLNs, ATLOs and plaques are compared.

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