Extended Data Fig. 5: ALPK3 deficient cardiomyocytes have compromised expression of key cardiac protein networks. | Nature Cardiovascular Research

Extended Data Fig. 5: ALPK3 deficient cardiomyocytes have compromised expression of key cardiac protein networks.

From: Alpha kinase 3 signaling at the M-band maintains sarcomere integrity and proteostasis in striated muscle

Extended Data Fig. 5: ALPK3 deficient cardiomyocytes have compromised expression of key cardiac protein networks.

a Experimental outline of proteomics experiment. n = 5 per group. b Volcano plot of day 14 WT and ALPK3mut hPSC-CMs to show differential protein expression. c Gene ontology (GO) of biological processes enriched in differentially expressed proteins in day 14 WT and ALPK3mut hPSC-CMs. d Volcano plot of day 30 WT and ALPK3mut hPSC-CMs to show differential protein expression. e GO of biological processes enriched in differentially expressed proteins in day 30 WT and ALPK3mut hPSC-CMs. f Venn diagrams of protein expression up- or down-regulated proteins common for day 14 and day 30. g GO of biological processes of commonly up- or down-regulated proteins in ALPK3mut hPSC-CMs.

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