Extended Data Fig. 3: Analysis of genes associated with cardiac contractility, stress and fibrosis in the hearts of male and female control and ERαHKO mice (>12 months). | Nature Cardiovascular Research

Extended Data Fig. 3: Analysis of genes associated with cardiac contractility, stress and fibrosis in the hearts of male and female control and ERαHKO mice (>12 months).

From: Estrogen receptor alpha deficiency in cardiomyocytes reprograms the heart-derived extracellular vesicle proteome and induces obesity in female mice

Extended Data Fig. 3: Analysis of genes associated with cardiac contractility, stress and fibrosis in the hearts of male and female control and ERαHKO mice (>12 months).The alternative text for this image may have been generated using AI.

a, Gene expression of SERCA2a, αMHC, and βMHC relative to Hprt1 by qPCR in male control (FC) and knockout (KO) hearts. Lines show mean±SEM. FC n=4, KO n=7. Gene expression of atrial natriuretic peptide (ANP, Npaa), B-Type natriuretic peptide (BNP, Nppb), Collagen 1 and 3 relative to Hprt1 in b, Male and c, Female FC and KO hearts. Lines show mean±SEM. Male FC n=4, Male KO n=7, Female FC n=8, Female KO n=7; n represent data from independent animals. For all panels, two-sided, unpaired t-test; no significant differences between groups.

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