Extended Data Fig. 6: ABRA expression enriched in unloaded group.
From: Defining cardiac functional recovery in end-stage heart failure at single-cell resolution
(A) DotPlot of cardiomyocyte specific recovery up- and down signature grouped by CM cell states. (B) Density plot of ABRA expression in UMAP embedding. (C) DotPlot of ABRA expression in cardiomyocytes grouped by condition. (D) RNAscope images of ABRA in 5 conditions and scale bar is 100 um. (E) RNAscope images quantified across an array of patients. N = 37 biologically independent samples and p-values calculated using Wald test adjusted for multiple corrections; donor vs U-pre (*P = 0.023), U-pre vs RR-pre (***P < 0.0001), U-pre vs RR-post (***P = 0.0003), U-post vs RR-pre (***P = 0.0007), U-post vs RR-post (*P = 0.0188), and RR-pre vs RR-post (***P = 0.0007).
