Extended Data Fig. 1: Expanded genetic data graphs for rs2234962, BAG3C151R, along with conservation of residues affected by BAG3C151R and BAG3E455K variants.
From: Functional analysis of a common BAG3 allele associated with protection from heart failure
(a) Zoomed out version of Fig. 1a, showing a window of 200KB. Dot color indicates type of nucleotide change. (b) Allele frequency map for rs2234962 depicting all 1000 Genomes populations. (c) Top: Diagram of BAG3 domain structure. Bottom: Amino acid conservation plot for matching BAG3 regions. Decreasing Relative Substitution Score regions (valleys) indicate sequences with high conservation across species and are annotated as Evolutionary Constrained Regions (ECRs). (D-E) Zoomed in regions for the ECRs around BAG3C151(d) and BAG3E455(e).
