Extended Data Fig. 5: Multiple-sequence alignment of human ABCC4 and homologs.
From: Structural insights into human ABCC4-mediated transport of platelet agonist and antagonist
Black triangles indicate the binding residues in the substrate-binding pocket of ABCC4. Notably, residues Leu321, Leu363 and Met992 involved in the interaction with dipyridamole are labeled with red triangles, whereas residues His152, Phe156 interacting with U46619 in ATP-bound ABCC4 and Thr846 interacting with aspirin are labeled with blue triangles. All the primary sequences were provided as a Source Data file.
