Table 1 Summary of the baits included in the study and the cardiac currents the channels conduct. The antibodies were selected on the basis of MS experiments wherein they captured the channel of interest among the top five most abundant proteins
From: Outlining cardiac ion channel protein interactors and their signature in the human electrocardiogram
Gene | Protein | Protein symbol | Class | Current |
|---|---|---|---|---|
Cacna1c | Cav1.2 | Cacna1c | Ca2+ channel | ICa,L |
Gja1 | Cx43 | Gja1 | Gap junction channel | Gj |
Hcn4 | HCN4 | Hcn4 | Funny channel | If |
Kcnma1 | BK | Kcnma1 | Calcium-activated K+ channel | IKCa,2 |
Kcnn3 | KCa2.3/SK3 | Kcnn3 | Calcium-activated K+ channel | IKCa,1 |
Kcnj2 | Kir2.1 | Kcnj2 | Inward rectifier K+ channel | IKir |
Kcnj3 | Kir3.1 | Kcnj3 | Inward rectifier K+ channel | IK,ACh |
Kcnj5 | Kir3.4 | Kcnj5 | Inward rectifier K+ channel | IK,ACh |
Kcnh2 | Kv11.1/ERG | Kcnh2 | Delayed rectifier K+ channel | IK,r |
Kcna5 | Kv1.5 | Kcna5 | Shaker-related K+ channel | IKur |
Kcnd2 | Kv4.2 | Kcnd2 | Subfamily D K+ channel | Ito1 |
Kcnq1 | Kv7.1/Kcnq1 | Kcnq1 | Delayed rectifier K+ channel | IK,s |
Scn5a | Nav1.5 | Scn5a | Na+ channel | INa |
