Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Comment
  • Published:

Dual SGLT1 and SGLT2 inhibitor sotagliflozin achieves FDA approval: landmark or landmine?

Nature Cardiovascular Research volume 2, pages 705–707 (2023) Cite this article

Subjects

The US Food and Drug Administration (FDA) has approved sotagliflozin with a broad heart-failure indication, even in the absence of trial data in patients without diabetes. No one knows what the benefits or risks of inhibiting SGLT1 in the heart might be.

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Buy this article

  • Purchase on SpringerLink
  • Instant access to the full article PDF.

USD 39.95

Prices may be subject to local taxes which are calculated during checkout

Fig. 1: Effects of sotaglifozin.
The alternative text for this image may have been generated using AI.

References

  1. Borges-Júnior, F. A. et al. J. Am. Soc. Nephrol. 32, 1616–1629 (2021).

    Article  PubMed  PubMed Central  Google Scholar 

  2. Packer, M. Circulation 146, 1383–1405 (2022).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  3. Chan, L. K. Y., Wang, Y., Ng, E. K. W. & Leung, P. S. Diabetes Obes. Metab. 20, 709–717 (2018).

    Article  CAS  PubMed  Google Scholar 

  4. Turk, E., Zabel, B., Mundlos, S., Dyer, J. & Wright, E. M. Nature 350, 354–356 (1991).

    Article  CAS  PubMed  Google Scholar 

  5. SCORED Investigators. N. Engl. J. Med. 384, 129–139 (2021).

    Article  Google Scholar 

  6. SOLOIST-WHF Trial Investigators. N. Engl. J. Med. 384, 117–128 (2021).

    Article  Google Scholar 

  7. US FDA. INPEFA (sotagliflozin) tablets, for oral use. https://go.nature.com/3CVjPBw (2023).

  8. van Raalte, D. H. et al. Diabetes Care 42, 1921–1929 (2019).

    Article  PubMed  PubMed Central  Google Scholar 

  9. Sayour, A. A. et al. Cardiovasc Diabetol. 19, 159 (2020).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  10. Ramratnam, M. et al. J. Am. Heart Assoc. 3, e000899 (2014).

    Article  PubMed  PubMed Central  Google Scholar 

  11. Connelly, K. A., Zhang, Y., Desjardins, J. F., Thai, K. & Gilbert, R. E. Cardiovasc. Diabetol. 17, 99 (2018).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  12. Ferté, L. et al. Am. J. Physiol. Heart Circ. Physiol. 320, H838–H853 (2021).

    Article  PubMed  PubMed Central  Google Scholar 

  13. Takebayashi, K. & Inukai, T. J. Clin. Med. Res. 9, 745–753 (2017).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  14. Posch, M. G. et al. Diabetes Care 45, 2118–2126 (2022).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  15. Sudo, M. et al. Atherosclerosis 265, 283–291 (2017).

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Baylor Heart and Vascular Institute, Dallas, TX, USA

    Milton Packer

  2. Imperial College, London, UK

    Milton Packer

Authors
  1. Milton Packer
    View author publications

    Search author on:PubMed Google Scholar

Corresponding author

Correspondence to Milton Packer.

Ethics declarations

Competing interests

In the past three years, M.P. has been a consultant to 89bio, Abbvie, Altimmune, Amgen, Ardelyx, AstraZeneca, Boehringer Ingelheim, Caladrius, Casana, CSL Behring, Cytokinetics, Imara, Lilly, Moderna, Novartis, Pharmacosmos, Reata, Regeneron, Relypsa and Salamandra.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Packer, M. Dual SGLT1 and SGLT2 inhibitor sotagliflozin achieves FDA approval: landmark or landmine?. Nat Cardiovasc Res 2, 705–707 (2023). https://doi.org/10.1038/s44161-023-00306-x

Download citation

  • Published:

  • Version of record:

  • Issue date:

  • DOI: https://doi.org/10.1038/s44161-023-00306-x

This article is cited by

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing