Extended Data Fig. 2: JOSD2 deficiency promotes TAC-induced cardiac hypertrophy and dysfunction. | Nature Cardiovascular Research

Extended Data Fig. 2: JOSD2 deficiency promotes TAC-induced cardiac hypertrophy and dysfunction.

From: Deubiquitinase JOSD2 improves calcium handling and attenuates cardiac hypertrophy and dysfunction by stabilizing SERCA2a in cardiomyocytes

Extended Data Fig. 2: JOSD2 deficiency promotes TAC-induced cardiac hypertrophy and dysfunction.The alternative text for this image may have been generated using AI.

Josd2−/− mice and WT mice were undergoing TAC or sham operations for 4 weeks. (a) Representative flow doppler ultrasound images of the aortic arch (left) and transverse aortic flow velocity (right) in Sham or TAC mice. (b) Mice body weight during study. (c) Representative images of HE staining of heart sections (longitudinal). (d,e) Representative images of Masson trichrome staining of the hearts sections and quantitative analysis. (f,g) RT-qPCR analysis of Col-1a1, Tgf-β, Myh7, Bnp and Anp, in cardiac tissues. (n = 6 for each group. For a, P value was determined by two-tailed unpaired t-test. For e, f and g, P values were determined by one-way ANOVA with Bonferroni’s correction. For a,b, e, f and g, data are presented as mean ± SEM).

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