Extended Data Fig. 5: Regulated genes in DNMT3A mutant monocytes and DNMT3A-silenced THP1 macrophages. | Nature Cardiovascular Research

Extended Data Fig. 5: Regulated genes in DNMT3A mutant monocytes and DNMT3A-silenced THP1 macrophages.

From: Cell-intrinsic effects of clonal hematopoiesis in heart failure

Extended Data Fig. 5

a. Violin plots of significantly upregulated genes in mutant vs. wild type cells in monocytes of patients. b. Violin plots of significantly upregulated genes in responsive DNMT3A silenced THP1 cells. c. Violin plots of significantly downregulated genes in mutant vs. wild type cells in monocytes of patients. (Panels a/c: n = 5 for pooled analysis. Panels b: n = 644 siDNMT3A non-reponsive cells, n = 387 siDNMT3A responsive cells. (Significance denoted by * and reflects adj. p-value < 0.05).

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