Extended Data Fig. 1: In vivo cardiac phenotyping of mice with disrupted propionyl-CoA handling. | Nature Cardiovascular Research

Extended Data Fig. 1: In vivo cardiac phenotyping of mice with disrupted propionyl-CoA handling.

From: Disrupted propionate metabolism evokes transcriptional changes in the heart by increasing histone acetylation and propionylation

Extended Data Fig. 1: In vivo cardiac phenotyping of mice with disrupted propionyl-CoA handling.The alternative text for this image may have been generated using AI.

(a) Exemplar electrocardiogram recorded in lead II, showing waves and intervals, in 8-week-old amPA or amWT mice. Heart rate, intervals and wave amplitudes (N = 8, 12, 14, 8). Two-way ANOVA with Tukey’s multiple comparisons test. Mean ± SEM. (b) Echocardiography of female mice scanned at 8 weeks of age. Body weight of mice used for echocardiography, E/E’ and E’/A’ ratio measured from pulsed-wave and Tissue Doppler in apical four-chamber view; stroke volume and cardiac output measured from M-mode scans in the parasternal short-axis view (N = 15, 8). Significance tested by regression analysis. Mean ± SEM.

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